Below is a common error that comes up when you install Exchange 2007 Server on a Windows 2008 Server. The hub transport role fails with an error “MsExchange transport failed to reach status running on this server”. Mailbox & CAS installations are cancelled as well, if it is a typical exchange 2007 installation.
Solution is to enable IPV6 in NIC properties, but disable IPV6 in registry and re-run the setup.
To disable IPV6 fully on the 2008 server. Follow the steps to do so.
Launch registry, navigate to HKEY_LOCAL_MACHINESYSTEMCurrentControlSetServicesTcpip6Parameters. In the details pane, click New, and then click DWORD (32-bit) Value. Type “DisabledComponents” (without quotes) and then press enter. Double-click DisabledComponents and type 0xffffffff in Hexadecimal or 4294967295 in Decimal. Close the registry editor.
Now, navigate to C:WindowsSystem32DriversEtc and open the hosts file in notepad. Delete the IPV6 entry.