The Exchange team has released update rollup 5 for Exchange 2010 SP2 deployments.
Exchange 2010 SP2 is the minimum requirement for this rollup. As always, it is a cumulative rollup and can be applied without installing the previous ones. Forefront needs to be disabled before installing the update by running fscutility /disable and enabled after the installation.
The required services are restarted during the rollup installation and hence a server restart is not required.